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16 Feb 19
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AN OPEN LETTER TO PROF MAHMOOD YAKUBU INEC BOSS ON BEHALF OF ALL CORP MEMBERS IN NIGERIA Dear Mr Chairman, We thank you and your entire staff for your resilience and commitment towards giving Nigerians a credible election. We also wish to draw your attention to the plight and neglect which we the members of […]

16 Feb 19
Mc warri entertainment

AN OPEN LETTER TO PROF MAHMOOD YAKUBU INEC BOSS ON BEHALF OF ALL CORP MEMBERS IN NIGERIA Dear Mr Chairman, We thank you and your entire staff for your resilience and commitment towards giving Nigerians a credible election. We also wish to draw your attention to the plight and neglect which we the members of […]

16 Feb 19
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16 Feb 19
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16 Feb 19
Autism Advocacy Network

Icon for Nature Publishing Group Icon for PubMed Central Related Articles

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Mol Psychiatry. 2018 02;23(2):271-281

Authors: Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ

Abstract
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal-regulated kinase 1/2 and Fyn. Here we show that STEP61 is elevated in the cortex in the Nrg1+/- knockout mouse model of schizophrenia (SZ). Genetic reduction or pharmacological inhibition of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in Nrg1+/- mice. STEP61 protein is also increased in cortical lysates from the central nervous system-specific ErbB2/4 mouse model of SZ, as well as in human induced pluripotent stem cell (hiPSC)-derived forebrain neurons and Ngn2-induced excitatory neurons, from two independent SZ patient cohorts. In these selected SZ models, increased STEP61 protein levels likely reflect reduced ubiquitination and degradation. These convergent findings from mouse and hiPSC SZ models provide evidence for STEP61 dysfunction in SZ.

PMID: 27752082 [PubMed – indexed for MEDLINE]

16 Feb 19
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16 Feb 19
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16 Feb 19
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He died at the age of 77 years in Zurich. Ganz achieved great fame, among other things, by his role as Adolf Hitler in "The Downfall". The Swiss actor Bruno Ganz is dead. He died last night at the age of 77 in his home in Zurich. Ganz was considered one of the most important […]

16 Feb 19
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Many technical skills require training and experience to master. They are also typically a type of hard skill. Hard skills are those that can be taught in a classroom, and can be defined, evaluated, and measured (as opposed to soft skills, which are personal attributes that help you succeed at work). This list of technical skills can come […]

16 Feb 19
Islamic Gems

The greatness of Islam lies in its realistic idealism. The word of truth, which was descended upon the prophet PBUH, was revealed to a person (the prophet PBUH) who carried it out thereafter, and this is exactly what arouses our yearning to obey Allah knowing that this word of truth was carried out, and if […]

16 Feb 19
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16 Feb 19
Archy news nety

Trump fights with reporters in the Rose Garden of the White House. Above all, the question on which data basis the US President claims that there is a national emergency on the border with Mexico, which he has just proclaimed. Trump seems to have little desire to answer the questions. From Thorsten Denkler, New York […]